While Topps has produced baseball cards since 1952, some sets and certain cards within sets stand out as being far more desired and valuable than others. Whether it’s rookie cards of legendary players, special subset cards featuring huge stars, or error cards with misprints, there are always particular Topps issues that generate immense interest from collectors. Considering how much the hobby has grown in recent decades, it’s understandable why some vintage and modern releases featuring all-time greats command top dollar on the secondary market.

Let’s take a look at some of the hottest and most expensive Topps baseball cards across different eras that continue capturing collectors’ attention and big money at auction. From the early 1960s through the late 1980s boom years, rookie and star cards like the ones below helped cement Topps as the dominant brand in the industry.

1962 Topps Mickey Mantle #312 – Widely regarded as the crown jewel of the entire Mantle collection and one of the most iconic cards in the hobby. In pristine Mint/Near Mint condition, this highly sought-after rookie fetches well over $100,000. Even low-grade examples still sell for tens of thousands.

1965 Topps Sandy Koufax #130 – Whether it’s due to his dominance on the mound or shorter than expected career length after arthritis forced his early retirement, Koufax rookie cards maintain stratospheric values. PSA 10 Gems easily clear six figures at auction.

1968 Topps Nolan Ryan #500 – Ryan’s first Topps issue features one of the game’s most legendary flamethrowers in an Angels uniform. While not quite as scarce as other vintage greats, this highly coveted rookie still isn’t cheap – especially for high-grade copies.

1972 Topps Johnny Bench #90 – Arguably the top catcher in MLB history, Bench’s iconic Topps rookie with him posed catching continues being a benchmark issue for the 1970s. Even low-grade examples command big money thanks to his Hall of Fame status.

1975 Topps Mike Schmidt #30 – Many consider Schmidt’s rookie among the most visually striking in the entire set due to its blue and red color scheme. High grades of his Phillies debut are several thousand dollar cards.

1981 Topps Traded Fernando Valenzuela #T81-3 – During his 1980 Rookie of the Year campaign, “Fernandomania” took the country by storm. This overly scarce traded issue with a different photo than the base set regularly sells for over $1,000 PSA 10.

1986 Topps Mark McGwire #177 – McGwire’s minor league cameo may look like a standard player card at first glance, but represents his pre-rookie. Even in low grades, it remains an iconic piece of baseball memorabilia from the late 1980s boom.

1989 Topps Ken Griffey Jr. #1 – Widely considered the most visually appealing modern rookie card issued, Griffey’s Upper Deck RC gets all the attention. His slick Topps debut remains a fantastic pull as well in pristine condition.

1998 Topps Sammy Sosa #193 – The home run race between Sosa and McGwire captivated the country in 1998 and drove massive interest in their cards. Sosa’s historic 66 homer campaign makes this one of his best.

2001 Topps Ichiro Suzuki #123 – Ichiro took America by storm in his inaugural season, winning Rookie of the Year and setting the single-season hit record. He transcended the game globally and this stunning rookie reflects his popularity.

2007 Topps Ryan Braun #166 – Braun edged out Matt Wieters for top 2007 baseball rookie honors. High grades fetch thousands due to his long, productive career that included an MVP award in 2011.

2010 Topps Bryce Harper #331 – One of the most hyped prospects ever, Harper didn’t disappoint in his debut season. His flashy Topps rookie remains a standout modern card sought after by Nationals fans and investors alike.

While new issues from each year continue entering the collecting mainstream, cards featured above from the 1960s to early 2000s tend to see the most activity on the secondary market. Iconic rookies like those of Mantle, Koufax, Bench, Schmidt, and Griffey along with huge star seasons like McGwire’s 1998 campaign remain bellwethers that garner widespread collector demand. Modern defining pieces like Harper’s first Topps issue will continue growing in significance as his career progresses too. No matter the era, the hottest Topps cards usually depict legendary players from rookie seasons through huge statistical years that stand the test of time. Condition also plays a massive role, as highest-graded vintage and modern gems command exponentially more money at auction. With increased new collector interest and cards becoming true alternative investments, these elite Topps items will stay highly coveted for years ahead.