Yes, many Topps baseball cards from different decades can be quite valuable depending on the player, condition of the card, and rarity. Topps has produced baseball cards since the 1950s and some of their earliest releases contain many high value cards today that could sell for thousands or even tens of thousands of dollars in mint condition.
One of the most valuable and sought after Topps baseball cards is the 1952 Topps Mickey Mantle rookie card. Mantle went on to have a legendary Hall of Fame career with the New York Yankees and is considered one of the greatest players of all time. His 1952 Topps rookie card is exceptionally rare in high grades due to the fragile paper stock used in the 1950s. Several 1952 Mantle rookies have sold for over $1 million when graded mint or near mint condition. Even well cared for copies in excellent condition could still sell for $100,000 or more.
Another very valuable Topps rookie card from the 50s belongs to Babe Ruth from 1952-1953. Though it’s not technically his true rookie since he retired in the 1930s, it was the first card featuring Ruth issued by Topps. High grade examples have sold for over $500,000. Other 50s rookies that can reach six figures include Hank Aaron, Willie Mays, and Roberto Clemente depending on condition.
The 1960s were when Topps began using a higher quality cardboard stock for their cards which has helped 1960s rookie cards hold up better over decades compared to the fragile 1950s issues. One of the most famous and valuable 1960s rookies is the 1968 Nolan Ryan rookie card. Ryan went on to break numerous all-time pitching records and there is high demand for his first Topps card. In a near mint gem mint 10 grade, 1968 Nolan Ryan rookies have sold at auction for well over $100,000.
Two other sought after 1960s rookies within the six figure range include the 1965 Sandy Koufax ($150,000+) and 1969 Johnny Bench ($150,000+). Both players enjoyed Hall of Fame careers and their rookie cards are among the most coveted from that era. Other 60s rookies that routinely sell for $10,000 or more depending on condition include Roberto Clemente, Bob Gibson, and Steve Carlton.
From the 1970s top graded rookies such as the 1975 George Brett ($50,000+), 1979 Dave Parker ($30,000+), and 1973 Johnny Bench ($25,000+) are some of the most financially lucrative cards to own from that decade aside from complete sets. Rated rookies from the late 60s through 70s typically sell stronger than those from the 50s-60s due to having aged better through more durable construction.
The 1980s saw some spikes in card values for certain rookie stars such as the 1984 Dwight Gooden ($15,000+) and rookie cards of Donruss and Fleer variants also gained traction as Topps faced competition during that period. Well graded rookie cups and All-Star cards from Cal Ripken Jr., Roger Clemens, and Barry Bonds from the 80s can sell for thousands depending on the player and specific issue.
More modern 1990s superstars like the 1993 Ken Griffey Jr. rookie which has sold for over $100,000 can yield six figure sums in pristine condition. First cards of Chipper Jones, Derek Jeter, and Nomar Garciaparra are regularly in the thousands for high grades. Elite rookies from the late 90s through present day have gotten pricier more recently as the collecting hobby boomed.
While not all Topps cards are necessarily worth money, there are certainly dozens upon dozens of historically significant and rare rookie cards, complete sets, and unique variants from the 1950s through 90s produced by Topps that could be worth collecting and potentially sell for thousands or even six figure amounts depending on condition, player pedigree, and supply versus current demand from collectors. The earlier and higher the card grade, generally the more valuable a key Topps baseball card will be worth today for savvy investors and enthusiasts.