Ken Griffey Jr. Rookie Card (#116) – Griffey’s rookie card is arguably the most valuable card from the 1988 Topps set. In gem mint condition, the Griffey rookie has sold for over $400,000. Even well-worn copies in played condition can fetch $50-100. Griffey went on to have a Hall of Fame career and his rookie card remains one of the most iconic and sought after in the sport.

Nolan Ryan (#133) – As one of the greatest pitchers ever, any Nolan Ryan card from his playing days holds value. But his 1988 Topps card, which captures Ryan in a Houston Astros uniform, has additional significance as one of his final cards before retirement. Graded gems have sold for $1,000-3,000, while more played copies can bring $100-300 depending on condition.

Ozzie Smith (#144) – Like Griffey and Ryan, Ozzie Smith is recognized as one of the all-time greats at his position. His smooth fielding at shortstop made him a fan favorite. His 1988 Topps is from his later Cardinals years and has appeal to both vintage collectors and those focused on 80s/90s content. Mint copies have topped $500.

Rickey Henderson (#180) – The 1988 set came early in Henderson’s immense career, which saw him set the stolen base record and cement his case as the greatest leadoff hitter and basestealer ever. His rookie cards hold value, but this later Oakland A’s issue also has collector interest given Rickey’s accomplishments and legend status. Gem copies have sold for $300-500.

Mark McGwire (#236) – McGwire’s towering home runs made him a star in Oakland in the late 80s, and this card captures him pre-steroids controversy. It remains one of his more affordable early rookie/early career issues. Graded mint copies have sold for $150-300 depending on pop report numbers.

Jose Canseco (#308) – Canseco exploded onto the scene by winning AL Rookie of the Year and MVP in 1986. This 1988 card features him in his prime Oakland years. Canseco helped popularize the home run and remains a key figure in baseball’s steroid era. Even played condition copies sell in the $50-100 range.

Don Mattingly (#419) – Perhaps the most iconic Yankee of the 1980s, Mattingly’s batting prowess and NY ties make any of his Topps cards appealing to collectors. While not his true rookie issue, this card depicts the 1985 AL MVP and Batting Title winner at the height of his fame before injuries slowed him down. It usually sells for $75-150 graded.

Tom Glavine (#597) – Glavine’s rookie year was 1987 but his true rookie card was not issued until 1988 Topps. He went on to have a Hall of Fame career mainly with the Atlanta Braves and remains one of the best pitchers of the 1990s-2000s. Mint condition editions have crossed $300 at auction due to his significance as a rookie issue.

Other 1988 Topps cards that bring over $100 graded include Bo Jackson’s baseball rookie (#520), Barry Bonds (#563), and Randy Johnson’s rookie (#650). Generally speaking, the scarcer the player, the greater their accomplishments, or the higher their post-career fame – the more valuable that 1988 Topps card remains today, even for stars from the past like Steve Garvey (#66) and Tony Gwynn (#531). Condition, of course, is also critical – with any of these lasting five times more in mint versus played form.

The 1988 Topps set was the height of the junk wax era but still captured stars and rookies who went on to great careers. While repack boxes or common veterans may not be worth much, the select rookie cards and issues featuring true Hall of Famers from that year will always have a market for knowledgeable collectors. With the increased use of grading over the past decade and growth of online card sales, prices for conditioned versions of the stars from the 1988 Topps set have stabilized and some have seen renewed appreciation approach levels reminiscent of the early 1990s boom.